Hubei Yuancheng Pharmaceutical Co., Ltd.

Local Anesthetic Lidocaine

Lidocaine

Lidocaine Basic Information:

Product Name: Lidocaine 

Lidocaine CAS: 137-58-6 

Lidocaine MF: C14H22N2O 

Lidocaine MW: 234.34 

Lidocaine EINECS: 205-302-8 

Lidocaine mp:  66-69°C 

Lidocaine storage temp:  Store at RT 

Lidocaine solubility  ethanol: 4 mg/mL

Lidocaine form:  powder

Lidocaine Water Solubility:   practically insoluble 

Lidocaine Stability:   Stable. Incompatible with strong oxidizing agents. 

Lidocaine Usage:  Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. 

Lidocaine Description:

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action. Epinephrine (adrenaline) vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.Lidocaine drops can be used on the eyes for short ophthalmic procedures.

There is tentative evidence for topical lidocaine for neuropathic pain.Intravenous lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two-thirds.